Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity

Roy, S. ; Williams, C.M. ; Pardo, J. (Universidad de Zaragoza) ; Wijesundara, D.K. ; Furuya, Y.

Resumen: The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV.

Idioma: Inglés

DOI: 10.3390/vaccines8030459

Año: 2020

Publicado en: Vaccines 8, 3 (2020), 459 [1-6 pp.]
ISSN: 2076-393X

Factor impacto JCR: 4.422 (2020)

Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 63 / 140 = 0.45 (2020) - Q2 - T2
Categ. JCR: IMMUNOLOGY rank: 74 / 162 = 0.457 (2020) - Q2 - T2

Factor impacto SCIMAGO: 1.296 - Drug Discovery (Q1) - Immunology (Q1) - Pharmacology (medical) (Q1) - Pharmacology (Q1) - Infectious Diseases (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)