The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Gonzalez-Alvaro, I. ; Castrejon, I. ; Carmona, L. ; Dougados, M. ; Huizinga, T. ; Abu Shakra, M. ; Alberts, A. ; Lopez, M.A. ; Amital, H. ; Aringer, M. ; Aslanidis, S. ; Berenbaum, F. ; Bijlsma, H. ; Garcia, F.J.B. ; Bliddal, H. ; Borofsky, M. ; Brocq, O. ; Buldakov, S. ; Cantini, F. ; Perez, L.C. ; Chahade, W. ; Ciconelli, R. ; Codreanu, C. ; Dahlqvist, S.R. ; Damjanov, N. ; Diamantopoulos, A. ; Dimdina, L. ; Dimic, A. ; Dorokhov, A. ; Dubikov, A. ; Fadienko, G. ; Fano, N. ; Ferreira, G. ; Gabrielli, A. ; Gaffney, K. ; Gaudin, P. ; Gerlag, D.M. ; Gerli, R. ; Goncalves, C.R. ; Hansen, M.S. ; Hanvivadhanakul, P. ; Hoili, C. ; Hou, A. ; Hunter, J. ; Ilic, T. ; Ionescu, R. ; Kaine, J. ; Kakurina, N. ; Kamalova, R. ; Kelly, T. ; Knyazeva, L. ; Krumina, L. ; Kurthen, R. ; Lagrone, R.P. ; Lapadula, G. ; Lavrentjevs, V. ; Lawson, J.G. ; Lazic, Z. ; Lejnieks, A. ; Levy, Y. ; Lexberg, A. ; Mader, R. ; Mariette, X. ; Markovits, D. ; Mola, E.M. ; Maugars, Y. ; Guarch, J.M. ; Mazurov, V.I. ; Mikkelsen, K. ; Vergles, J.M. ; Nabizadeh, S. ; Nanagara, R. ; Nasonov, E.L. ; Sarabia, F.N. ; Neumann, T. ; Novak, S. ; Olech, E. ; Oza, M. ; Paran, D. ; Parsik, E. ; Pegram, S. ; Suarez, M.P. ; Popova, T. ; Puechal, X. ; Raja, N. ; Ridley, D. ; Rosner, I. ; Rubbert-Roth, A. ; Rudin, A. ; Saraux, A. ; Saulite-Kandevica, D. ; Settas, L. ; Sfikakis, P. ; Sheeran, T. ; Sizikov, A. ; Stamenkovic, D. ; Stefanovic, D. ; Stolow, J.B. ; Tan, A.L. ; Tebib, J. ; Tishler, M. ; Tony, H.P. ; Troum, O.M. ; Uaratanawong, S. ; Angulo, E.U. ; Valenzuela, G. ; van der Laken, K. ; Van Laar, J. ; van Riel, P.L.C.M. ; Vasilopoulos, D. ; Veldi, T. ; Vinogradova, I. ; Vosse, D. ; Wassenberg, S. ; Weidmann, C. ; Weitz, M. ; Wollenhaupt, J. ; Xavier, R. ; Yakupova, S. ; Zagar, I. ; Zavgorodnaja, T. ; Zemerova, E. ; Zisman, D. ; Zonova, E. ; Camona, L. ; Alcazar, L.A. ; de Miguel, C.A. ; Sanchez, J.L.A. ; Diez, A.A. ; Criado, A.B. ; Gualda, E.B. ; Serrano, M.A.B. ; Audera, J.B. ; Fabregat, J.B. ; Hernan, G.B. ; Fernandez, N.C. ; Casado, E. ; Mendez, L.C. ; Coro, M.C. ; Diaz, J.L.C. ; Cuesta, E. ; Areste, J.F. ; Gonzalez, M.F. ; Izquierdo, M.G. ; Meijide, J.A.G. ; Gomez, M.C.G. ; Ubeda, E.G. ; Centeno, E.G. ; Vaquero, C.G. ; Fernandez, M.J.G. ; Gomez, M.L.G. ; Hernandez, T.G. ; Gonzalez-Alvaro, I. ; Gomez, C.G.M. ; Delgado, Y.G. ; Masmitja, J.G. ; del Rio, A.H. ; Instxaurbe, A.R. ; Oyarzabal, M.V.I. ; Palop, J. ; Mas, A.J. ; Navarro, E.J. ; Padro, M.L. ; Longo, F.J.L. ; Santamaria, E.L. ; Manzano, J.M. ; Ruiz, F.J.M. ; Bernardo, I.M. ; Gonzalez, L.M. ; Mazzucheli, R. ; Medrano San Idelfonso, M. (Universidad de Zaragoza) ; Hernandez, A.N. ; Espanol, A.P. ; Callizo, E.P. ; Donate, J.Q. ; Lopez, P.R. ; Redondo, J.R. ; Gomez, M.R. ; Lopez, M.R. ; Pardo, R.R. ; Alvarez, J.S. ; Sala, R.S. ; Rey, J.S.R. ; Marsa, X.T. ; Martin, M.T. ; Martin, M.C.T. ; Garnica, I.U. ; de Diego, J.P.V. ; Valls, M. ; Garcia, V.V. ; Montejo, P.Z. ; Tabernero, J.Z. ; Balsa, A. ; Sanmarti, R. ; Cabezas, J.A. ; Cantalejo, M. ; Chamizo, E. ; Ciruelo, E. ; Corrales, A. ; Cruz, A. ; Diaz, C. ; Fiter, J. ; Freire, M.M. ; Galindo, M. ; de Vicuna, M.R.G. ; Gelman, S.M. ; Crespo, R.G. ; Fernandez, C.G. ; Fernandez, M.J.G. ; Hernandez, T.G. ; Gracia, A. ; Granados, J.

Resumen: Objective
To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria.

Methods
Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy).

Results
Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard.

Conclusion
HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s.

Idioma: Inglés

DOI: 10.1371/journal.pone.0214717

Año: 2019

Publicado en: PloS one 14, 4 (2019), e0214717 [19 pp]
ISSN: 1932-6203

Factor impacto JCR: 2.74 (2019)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 27 / 71 = 0.38 (2019) - Q2 - T2

Factor impacto SCIMAGO: 1.023 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00442
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/RD16-0012-0011

Tipo y forma: Article (Published version)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)