000096164 001__ 96164 000096164 005__ 20210902121854.0 000096164 0247_ $$2doi$$a10.3389/fphys.2020.566399 000096164 0248_ $$2sideral$$a120727 000096164 037__ $$aART-2020-120727 000096164 041__ $$aeng 000096164 100__ $$0(orcid)0000-0001-6025-5070$$aHernández-Vicente, A.$$uUniversidad de Zaragoza 000096164 245__ $$aHeart Rate Variability and Exceptional Longevity 000096164 260__ $$c2020 000096164 5060_ $$aAccess copy available to the general public$$fUnrestricted 000096164 5203_ $$aCentenarians are the paradigm of human extreme longevity and healthy aging, because they have postponed, if not avoided, mayor age-related diseases. The purpose of this study was to investigate potential differences in resting heart rate variability (HRV) between young adults, octogenarians, and centenarians and assess whether HRV variables are predictors of all-cause mortality in centenarians. To this end, three groups of participants: young adults (N = 20; 20.6 ± 2.3 years), octogenarians (N = 18; 84.1 ± 2.6 years), and centenarians (N = 17; 101.9 ± 1.9 years) were monitored for 15 min at rest (seated, without moving or talking) to measure RR intervals, from which HRV was evaluated. Our results showed a clear decrease with age in the main parasympathetic HRV variables, as well as in the standard deviation (SD) of the RR series [SD of normal-to-normal interval (SDNN)] and in low frequency (LF) heart rate (HR) oscillations, although differences between octogenarians and centenarians did not reach statistical significance. In 14 centenarians followed until death, only SDNN showed significant correlation (¿ = 0.536; p = 0.048) with survival prognosis. Additionally, SDNN <19 ms was associated with early mortality (=1 year) in centenarians (Hazard Ratio = 5.72). In conclusion, HRV indices reflecting parasympathetic outflow as well as SDNN and LF all present an age-related reduction, which could be representative of a natural exhaustion of allostatic systems related to age. Moreover, low SDNN values (<19 ms) could be associated with early mortality in centenarians. HRV seems to play a role in exceptional longevity, which could be accounted for by centenarians’ exposome. 000096164 536__ $$9info:eu-repo/grantAgreement/ES/MICIU/RTI2018-097723-B-I00$$9info:eu-repo/grantAgreement/ES/MICIU/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MECD/FPU16-05879$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18$$9info:eu-repo/grantAgreement/ES/DGA-FSE/LMP24-18$$9info:eu-repo/grantAgreement/ES/DGA-FSE/LMP124-18$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón 000096164 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000096164 590__ $$a4.566$$b2020 000096164 591__ $$aPHYSIOLOGY$$b14 / 81 = 0.173$$c2020$$dQ1$$eT1 000096164 592__ $$a1.32$$b2020 000096164 593__ $$aPhysiology (medical)$$c2020$$dQ2 000096164 593__ $$aPhysiology$$c2020$$dQ2 000096164 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000096164 700__ $$0(orcid)0000-0002-1462-4880$$aHernando, D. 000096164 700__ $$aSantos-Lozano, A. 000096164 700__ $$aRodríguez-Romo, G. 000096164 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodríguez, G.$$uUniversidad de Zaragoza 000096164 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza 000096164 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, R.$$uUniversidad de Zaragoza 000096164 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, N.$$uUniversidad de Zaragoza 000096164 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor. 000096164 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac. 000096164 773__ $$g11 (2020), 566399 [9 pp]$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X 000096164 8564_ $$s271377$$uhttps://zaguan.unizar.es/record/96164/files/texto_completo.pdf$$yVersión publicada 000096164 8564_ $$s29197$$uhttps://zaguan.unizar.es/record/96164/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000096164 909CO $$ooai:zaguan.unizar.es:96164$$particulos$$pdriver 000096164 951__ $$a2021-09-02-10:31:33 000096164 980__ $$aARTICLE