000097169 001__ 97169
000097169 005__ 20230914083252.0
000097169 0247_ $$2doi$$a10.3390/pathogens9110928
000097169 0248_ $$2sideral$$a121080
000097169 037__ $$aART-2020-121080
000097169 041__ $$aeng
000097169 100__ $$aMullbacher, A.
000097169 245__ $$aSARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity
000097169 260__ $$c2020
000097169 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097169 5203_ $$aDespite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.
000097169 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/Fondo-COVID19$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R$$9info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R
000097169 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097169 590__ $$a3.492$$b2020
000097169 591__ $$aMICROBIOLOGY$$b67 / 135 = 0.496$$c2020$$dQ2$$eT2
000097169 592__ $$a0.983$$b2020
000097169 593__ $$aImmunology and Allergy$$c2020$$dQ2
000097169 593__ $$aMolecular Biology$$c2020$$dQ2
000097169 593__ $$aMicrobiology (medical)$$c2020$$dQ2
000097169 593__ $$aInfectious Diseases$$c2020$$dQ2
000097169 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097169 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, J.$$uUniversidad de Zaragoza
000097169 700__ $$aFuruya, Y.
000097169 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000097169 773__ $$g9, 11 (2020), 928 [5 pp]$$pPathogens$$tPathogens$$x2076-0817
000097169 8564_ $$s129699$$uhttps://zaguan.unizar.es/record/97169/files/texto_completo.pdf$$yVersión publicada
000097169 8564_ $$s511925$$uhttps://zaguan.unizar.es/record/97169/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097169 909CO $$ooai:zaguan.unizar.es:97169$$particulos$$pdriver
000097169 951__ $$a2023-09-13-10:51:08
000097169 980__ $$aARTICLE