SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

Mullbacher, A. ; Pardo, J. (Universidad de Zaragoza) ; Furuya, Y.

Resumen: Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.

Idioma: Inglés

DOI: 10.3390/pathogens9110928

Año: 2020

Publicado en: Pathogens 9, 11 (2020), 928 [5 pp]
ISSN: 2076-0817

Factor impacto JCR: 3.492 (2020)

Categ. JCR: MICROBIOLOGY rank: 67 / 135 = 0.496 (2020) - Q2 - T2

Factor impacto SCIMAGO: 0.983 - Immunology and Allergy (Q2) - Molecular Biology (Q2) - Microbiology (medical) (Q2) - Infectious Diseases (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/Fondo-COVID19
Financiación: info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)