000097382 001__ 97382
000097382 005__ 20210902121933.0
000097382 0247_ $$2doi$$a10.3390/polym12122872
000097382 0248_ $$2sideral$$a121767
000097382 037__ $$aART-2020-121767
000097382 041__ $$aeng
000097382 100__ $$0(orcid)0000-0002-8932-9085$$aConcellón, A.
000097382 245__ $$aMicellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties
000097382 260__ $$c2020
000097382 5060_ $$aAccess copy available to the general public$$fUnrestricted
000097382 5203_ $$aThe design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.
000097382 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-17R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-097583-B-I00
000097382 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000097382 590__ $$a4.329$$b2020
000097382 591__ $$aPOLYMER SCIENCE$$b18 / 88 = 0.205$$c2020$$dQ1$$eT1
000097382 592__ $$a0.77$$b2020
000097382 593__ $$aPolymers and Plastics$$c2020$$dQ1
000097382 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1
000097382 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000097382 700__ $$0(orcid)0000-0003-0063-9456$$aAnselmo, M.S.$$uUniversidad de Zaragoza
000097382 700__ $$0(orcid)0000-0003-3109-4284$$aHernández-Ainsa, S.$$uUniversidad de Zaragoza
000097382 700__ $$0(orcid)0000-0003-1378-0571$$aRomero, P.$$uUniversidad de Zaragoza
000097382 700__ $$0(orcid)0000-0001-7056-3181$$aMarcos, M.
000097382 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano, J.L.$$uUniversidad de Zaragoza
000097382 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000097382 773__ $$g12, 12 (2020), 2872 [1-11]$$pPolymers (Basel)$$tPOLYMERS$$x2073-4360
000097382 8564_ $$s1484816$$uhttps://zaguan.unizar.es/record/97382/files/texto_completo.pdf$$yVersión publicada
000097382 8564_ $$s497804$$uhttps://zaguan.unizar.es/record/97382/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000097382 909CO $$ooai:zaguan.unizar.es:97382$$particulos$$pdriver
000097382 951__ $$a2021-09-02-10:56:24
000097382 980__ $$aARTICLE