Micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties

Concellón, A. ; Anselmo, M.S. (Universidad de Zaragoza) ; Hernández-Ainsa, S. (Universidad de Zaragoza) ; Romero, P. (Universidad de Zaragoza) ; Marcos, M. ; Serrano, J.L. (Universidad de Zaragoza)

Resumen: The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.

Idioma: Inglés

DOI: 10.3390/polym12122872

Año: 2020

Publicado en: POLYMERS 12, 12 (2020), 2872 [1-11]
ISSN: 2073-4360

Factor impacto JCR: 4.329 (2020)

Categ. JCR: POLYMER SCIENCE rank: 18 / 88 = 0.205 (2020) - Q1 - T1

Factor impacto SCIMAGO: 0.77 - Polymers and Plastics (Q1) - Chemistry (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-097583-B-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)