Resumen: This work provides an unprecedented example of a chiral aromatic amine used to activate a, b-unsaturated ketones in asymmetric aminocatalysis. Chiral aromatic diamine VII has been efficiently employed, as a proof of concept, in the Michael addition reaction between benzylideneacetones (1a-f) and coumarins (2a-d). The reaction gives rise to warfarin derivatives 3 with promising results using this family of catalysts for the first time. The additional studies performed supported the bifunctional mode of activation of the chiral catalyst VII and the covalent nature of the interactions between the catalyst VII and benzylideneacetones 1. Idioma: Inglés DOI: 10.1039/c9nj02392e Año: 2019 Publicado en: NEW JOURNAL OF CHEMISTRY 43, 31 (2019), 12233-12240 ISSN: 1144-0546 Factor impacto JCR: 3.288 (2019) Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 68 / 177 = 0.384 (2019) - Q2 - T2 Factor impacto SCIMAGO: 0.712 - Materials Chemistry (Q1) - Chemistry (miscellaneous) (Q2) - Catalysis (Q3)