Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging

Palacios, S. (Universidad de Zaragoza) ; Caiani, E.G. ; Pueyo, E. (Universidad de Zaragoza) ; Martínez, J.P. (Universidad de Zaragoza)

Resumen: Head-Down Bed Rest (HDBR) microgravity simulation induces cardiovascular deconditioning, including effects on ventricular repolarization. The index of Periodic Repolarization Dynamics (PRD) was developed to quantify low-frequency oscillations of cardiac repolarization. In this study, PRD was quantified by Phase Rectified Signal Averaging (PRDPRSA) and Continuous Wavelet Transform (PRDCWT) methods. PRD was analyzed in ECGs from 22 volunteers at rest and during orthostatic Tilt-Table Test (TTT) performed before and after -6° 60-days HDBR. Significant correlation was found between PRD measured by PRSA and CWT (Pearson''s ¿ = 0.93, p < 10-54 and Kendall''s t = 0.79 p < 10-38). A highly significant increase was found when PRDPRSA values were measured at POST-HDBR with respect to PRE-HDBR in the tilt phase: 1.40 [1.10] deg and 0.97 [0.90] deg (median [IQR]), p = 0.008, respectively. PRDPRSA also increased significantly in the tilt phase with respect to baseline, both at POST-HDBR (0.90 [0.57] deg, p = 0.003) and at PRE-HDBR (0.75 [0.45] deg, p = 0.011). PRD, either measured with PRSA or with CWT, is able to measure changes in ventricular repolarization induced by microgravity simulation as well as following sympathetic provocation.

Idioma: Inglés

DOI: 10.23919/CinC49843.2019.9005875

Año: 2019

Publicado en: Computing in Cardiology 46 (2019), [4 pp]
ISSN: 2325-8861

Factor impacto SCIMAGO: 0.296 - Computer Science (miscellaneous) - Cardiology and Cardiovascular Medicine

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS
Financiación: info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R

Tipo y forma: Article (Published version)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)