000098335 001__ 98335
000098335 005__ 20210126163933.0
000098335 0248_ $$2sideral$$a122078
000098335 037__ $$aART-2019-122078
000098335 041__ $$aeng
000098335 100__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, M.$$uUniversidad de Zaragoza
000098335 245__ $$aCombination of exosomes and near-infrared responsive gold nanoparticles: new selective and specific therapeutic vehicle
000098335 260__ $$c2019
000098335 5060_ $$aAccess copy available to the general public$$fUnrestricted
000098335 5203_ $$aP602
Exosomes are extracellular vesicles (50 -150 nm of diameter) considered key elements for the intercellular communication. Although they are proposed to be ideal vehicles for the targeting of novel therapies, very little is known about the selectiveness and specificity of the transference processes involving exosomes released from different cells. PEGylated Hollow gold nanoparticles (PEG-HGNs) are near-infrared (NIR) responsive nanoparticles (NPs) which are able to generate localized heat by the use of NIR light leading to cell death when applying optical hyperthermia. In this study, we demonstrate the selectivity of in vitro exosomal transfer between certain cell types and how this phenomenon can be exploited to develop new specific vectors for advanced therapies. Firstly, PEG-HGNs were successfully incorporated in the exosome biogenesis pathway of placental stem cells (MSCs) and they were released as PEG-HGNs-loaded exosomes (PEGHGNs_ MSCs_EXOs). Exosomes were characterized by confocal microscopy, western blot, nanosight, zeta potential and electronic microscopy. Afterwards, time lapse microscopy and atomic emission spectroscopy demonstrated the selective transfer of the ...
000098335 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000098335 590__ $$a4.273$$b2019
000098335 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b30 / 156 = 0.192$$c2019$$dQ1$$eT1
000098335 591__ $$aGENETICS & HEREDITY$$b38 / 177 = 0.215$$c2019$$dQ1$$eT1
000098335 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b40 / 138 = 0.29$$c2019$$dQ2$$eT1
000098335 592__ $$a1.648$$b2019
000098335 593__ $$aGenetics$$c2019$$dQ1
000098335 593__ $$aMolecular Medicine$$c2019$$dQ1
000098335 593__ $$aMolecular Biology$$c2019$$dQ2
000098335 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000098335 700__ $$0(orcid)0000-0003-3363-2912$$aNavascues, N.
000098335 700__ $$aMendoza, G.
000098335 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000098335 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000098335 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, P.
000098335 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, J.$$uUniversidad de Zaragoza
000098335 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000098335 773__ $$g30, 11 (2019), A192$$pHum. gene ther.$$tHUMAN GENE THERAPY$$x1043-0342
000098335 85641 $$uhttps://www.liebertpub.com/doi/pdf/10.1089/hum.2019.29095.abstracts$$zTexto completo de la revista
000098335 8564_ $$s45274$$uhttps://zaguan.unizar.es/record/98335/files/texto_completo.pdf$$yVersión publicada
000098335 8564_ $$s3573311$$uhttps://zaguan.unizar.es/record/98335/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000098335 909CO $$ooai:zaguan.unizar.es:98335$$particulos$$pdriver
000098335 951__ $$a2021-01-26-15:09:18
000098335 980__ $$aARTICLE