Growth performance and clinicopathological analyses in lambs repetitively inoculated with aluminum-hydroxide containing vaccines or aluminum-hydroxide only

de Miguel, R. (Universidad de Zaragoza) ; Asín, J. ; Rodríguez-Largo, A. (Universidad de Zaragoza) ; Echeverría, I. ; Lacasta, D. (Universidad de Zaragoza) ; Pinczowski, P. ; Gimeno, M. ; Molín, J. ; Fernández, A. (Universidad de Zaragoza) ; de Blas, I. (Universidad de Zaragoza) ; de Andrés, D. ; Pérez, M. (Universidad de Zaragoza) ; Reina, R. ; Luján, L. (Universidad de Zaragoza)

Resumen: Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep— the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.

Idioma: Inglés

DOI: 10.3390/ani11010146

Año: 2021

Publicado en: Animals 11, 1 (2021), 146 [18 pp]
ISSN: 2076-2615

Factor impacto JCR: 3.231 (2021)

Categ. JCR: VETERINARY SCIENCES rank: 16 / 145 = 0.11 (2021) - Q1 - T1
Categ. JCR: AGRICULTURE, DAIRY & ANIMAL SCIENCE rank: 13 / 62 = 0.21 (2021) - Q1 - T1

Factor impacto CITESCORE: 2.7 - Veterinary (Q2) - Agricultural and Biological Sciences (Q2)

Factor impacto SCIMAGO: 0.61 - Veterinary (miscellaneous) (Q1) - Animal Science and Zoology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/A17-17R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C31
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C33
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-2-R

Tipo y forma: Article (Published version)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)