000099381 001__ 99381
000099381 005__ 20240912131720.0
000099381 0247_ $$2doi$$a10.1093/europace/euv320
000099381 0248_ $$2sideral$$a122799
000099381 037__ $$aART-2015-122799
000099381 041__ $$aeng
000099381 100__ $$aRodriguez, Blanca
000099381 245__ $$aHuman-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
000099381 260__ $$c2015
000099381 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099381 5203_ $$aBoth biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in
health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed
computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on
Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a
human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards humanbased
methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the
limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental
and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The
effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with
experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary
approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines
and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships
supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and
overcome in each specific setting.
000099381 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099381 590__ $$a4.021$$b2015
000099381 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b32 / 124 = 0.258$$c2015$$dQ2$$eT1
000099381 592__ $$a2.412$$b2015
000099381 593__ $$aPhysiology (medical)$$c2015$$dQ1
000099381 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ1
000099381 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099381 700__ $$aCarusi, Annamaria
000099381 700__ $$aAbi-Gerges, Najah
000099381 700__ $$aAriga, Rina
000099381 700__ $$aBritton, Oliver
000099381 700__ $$aBub, Gil
000099381 700__ $$aBueno-Orovio, Alfonso
000099381 700__ $$aBurton, Rebecca A. B.
000099381 700__ $$aCarapella, Valentina
000099381 700__ $$aCardone-Noott, Louie
000099381 700__ $$aDaniels, Matthew J.
000099381 700__ $$aDavies, Mark R.
000099381 700__ $$aDutta, Sara
000099381 700__ $$aGhetti, Andre
000099381 700__ $$aGrau, Vicente
000099381 700__ $$aHarmer, Stephen
000099381 700__ $$aKopljar, Ivan
000099381 700__ $$aLambiase, Pier
000099381 700__ $$aRong Lu, Hua
000099381 700__ $$aLyon, Aurore
000099381 700__ $$0(orcid)0000-0003-3183-4107$$aMinchole, Ana
000099381 700__ $$aMuszkiewicz, Anna
000099381 700__ $$aOster, Julien
000099381 700__ $$aPaci, Michelangelo
000099381 700__ $$aPassini, Elisa
000099381 700__ $$aSeveri, Stefano
000099381 700__ $$aTaggart, Peter
000099381 700__ $$aTinker, Andy
000099381 700__ $$aValentin, Jean-Pierre
000099381 700__ $$aVarro, Andras
000099381 700__ $$aWallman, Mikael
000099381 700__ $$aZhou, Xin
000099381 773__ $$g18, 9 (2015), 1287 - 1298$$pEuropace$$tEuropace$$x1099-5129
000099381 8564_ $$s1116632$$uhttps://zaguan.unizar.es/record/99381/files/texto_completo.pdf$$yVersión publicada
000099381 8564_ $$s2765554$$uhttps://zaguan.unizar.es/record/99381/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000099381 951__ $$a2024-09-12-13:15:37
000099381 980__ $$aARTICLE