Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation: a Computational and Experimental Study

Celotto, Chiara (Universidad de Zaragoza) ; Sánchez Tapia, Carlos ; Mountris, Konstantinos ; Abdollahpur, Mostafa ; Sandberg, Frida ; Laguna Lasaosa, Pablo (Universidad de Zaragoza) ; Pueyo Paúles, Esther (Universidad de Zaragoza)

Resumen: The frequency of fibrillatory waves (f-waves), F f , exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (ΔF f ) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on F f and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075μM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 μM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean F f was dependent on mean [ACh] level, whileΔF f was dependent on [ACh] variation range.

Idioma: Inglés

DOI: 10.22489/CinC.2020.303

Año: 2020

Publicado en: Computing in Cardiology 47, ID303 (2020), [4 pp.]
ISSN: 2325-8861

Factor impacto SCIMAGO: 0.257 - Computer Science (miscellaneous) - Cardiology and Cardiovascular Medicine

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP124-18
Financiación: info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284
Financiación: info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PID2019-105674RB-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)