000099676 001__ 99676
000099676 005__ 20230519145515.0
000099676 0247_ $$2doi$$a10.3390/diagnostics11010136
000099676 0248_ $$2sideral$$a122871
000099676 037__ $$aART-2021-122871
000099676 041__ $$aeng
000099676 100__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, E.$$uUniversidad de Zaragoza
000099676 245__ $$aMicroperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy
000099676 260__ $$c2021
000099676 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099676 5203_ $$aBackground: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5 degrees nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.
000099676 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-7R$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/RD16-0008$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124
000099676 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099676 590__ $$a3.992$$b2021
000099676 592__ $$a0.658$$b2021
000099676 594__ $$a2.4$$b2021
000099676 591__ $$aMEDICINE, GENERAL & INTERNAL$$b60 / 172 = 0.349$$c2021$$dQ2$$eT2
000099676 593__ $$aClinical Biochemistry$$c2021$$dQ2
000099676 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099676 700__ $$aOtero-Rodriguez, J.
000099676 700__ $$0(orcid)0000-0002-9261-0302$$aPerdices, L.
000099676 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez-Cano, A.$$uUniversidad de Zaragoza
000099676 700__ $$aBoned-Murillo, A.
000099676 700__ $$0(orcid)0000-0002-2987-6351$$aAcha, J.$$uUniversidad de Zaragoza
000099676 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, I.$$uUniversidad de Zaragoza
000099676 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099676 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000099676 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000099676 773__ $$g11, 1 (2021), 136 [12 pp.]$$tDiagnostics$$x2075-4418
000099676 8564_ $$s6898682$$uhttps://zaguan.unizar.es/record/99676/files/texto_completo.pdf$$yVersión publicada
000099676 8564_ $$s2753612$$uhttps://zaguan.unizar.es/record/99676/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099676 909CO $$ooai:zaguan.unizar.es:99676$$particulos$$pdriver
000099676 951__ $$a2023-05-18-15:15:41
000099676 980__ $$aARTICLE