Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy

Orduna-Hospital, E. (Universidad de Zaragoza) ; Otero-Rodriguez, J. ; Perdices, L. ; Sanchez-Cano, A. (Universidad de Zaragoza) ; Boned-Murillo, A. ; Acha, J. (Universidad de Zaragoza) ; Pinilla, I. (Universidad de Zaragoza)

Resumen: Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5 degrees nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.

Idioma: Inglés

DOI: 10.3390/diagnostics11010136

Año: 2021

Publicado en: Diagnostics 11, 1 (2021), 136 [12 pp.]
ISSN: 2075-4418

Factor impacto JCR: 3.992 (2021)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 60 / 172 = 0.349 (2021) - Q2 - T2

Factor impacto CITESCORE: 2.4 - Biochemistry, Genetics and Molecular Biology (Q3)

Factor impacto SCIMAGO: 0.658 - Clinical Biochemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B08-7R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-MINECO/RD16-0008
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)