Neuroimmune response mediated by cytokines in natural scrapie after chronic dexamethasone treatment

Guijarro, I.M. ; Garcés, M. (Universidad de Zaragoza) ; Andrés-Benito, P. ; Marín, B. (Universidad de Zaragoza) ; Otero, A. (Universidad de Zaragoza) ; Barrio, T. ; Carmona, M. ; Ferrer, I. ; Badiola, J.J. (Universidad de Zaragoza) ; Monzón, M. (Universidad de Zaragoza)

Resumen: The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Addition-ally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.

Idioma: Inglés

DOI: 10.3390/biom11020204

Año: 2021

Publicado en: Biomolecules 11, 2 (2021), 204 [18 pp]
ISSN: 2218-273X

Factor impacto JCR: 6.064 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 75 / 297 = 0.253 (2021) - Q2 - T1

Factor impacto CITESCORE: 5.7 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.019 - Molecular Biology (Q2) - Biochemistry (Q2)

Financiación: info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU15-03524

Tipo y forma: Article (Published version)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)