In Vitro and In Vivo Antibacterial Activity of Gliotoxin Alone and in Combination with Antibiotics against Staphylococcus aureus

Esteban, P. ; Redrado, S. ; Comas, L. ; Domingo, M.P. ; Millán-Lou, M.I. ; Seral, C. (Universidad de Zaragoza) ; Algarate, S. (Universidad de Zaragoza) ; Lopez, C. (Universidad de Zaragoza) ; Rezusta, A. (Universidad de Zaragoza) ; Pardo, J. (Universidad de Zaragoza) ; Arias, M. ; Galvez, E.M.

Resumen: Multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of hospital-acquired and community infections and pose a challenge to the human health care system. Therefore, it is important to find new drugs that show activity against these bacteria, both in monotherapy and in combination with other antimicrobial drugs. Gliotoxin (GT) is a mycotoxin produced by Aspergillus fumigatus and other fungi of the Aspergillus genus. Some evidence suggests that GT shows antimicrobial activity against S. aureus in vitro, albeit its efficacy against multidrug-resistant strains such asMRSA or vancomycin-intermediate S. aureus (VISA) strainsis not known. This work aimedto evaluate the antibiotic efficacy of GT as monotherapy or in combination with other therapeutics against MRSA in vitro and in vivo using a Caenorhabditis elegans infection model.

Idioma: Inglés

DOI: 10.3390/toxins13020085

Año: 2021

Publicado en: Toxins 13, 2 (2021), 85 [16 pp]
ISSN: 2072-6651

Factor impacto JCR: 5.075 (2021)

Categ. JCR: TOXICOLOGY rank: 20 / 94 = 0.213 (2021) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 40 / 144 = 0.278 (2021) - Q2 - T1

Factor impacto CITESCORE: 6.6 - Pharmacology, Toxicology and Pharmaceutics (Q1) - Environmental Science (Q1)

Factor impacto SCIMAGO: 0.884 - Toxicology (Q1) - Health, Toxicology and Mutagenesis (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R
Financiación: info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)