Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain
Fuentes, A. ; Serrano-Conde, E. ; Roldán, C. ; Benito-Ruesca, R. (Universidad de Zaragoza) ; Mejías, G. ; Sampedro, A. ; March-Roselló, G. ; Fernández-Natal, I. ; Esperalba, J. ; Rodríguez, M.J. ; Martínez de Aguirre, P. ; Salas, C. ; Roc, M.L. ; Soria, L.M. ; Parra-Grande, M. ; Montero, M.D. ; Fernández-Roblas, R. ; Franco-Álvarez de Luna, F. ; Lozano, C. ; García, F.
Resumen: Aim: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic.
Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used.
Results: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively.
Conclusion: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19.
Idioma: Inglés
DOI: 10.1007/s10096-020-04139-5
Año: 2021
Publicado en: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 40 (2021), 1343–1349
ISSN: 0934-9723
Factor impacto JCR: 5.103 (2021)
Categ. JCR: MICROBIOLOGY rank: 49 / 138 = 0.355 (2021) - Q2 - T2
Categ. JCR: INFECTIOUS DISEASES rank: 41 / 96 = 0.427 (2021) - Q2 - T2
Factor impacto CITESCORE: 6.7 - Medicine (Q1)
Factor impacto SCIMAGO: 1.205 - Medicine (miscellaneous) (Q1) - Infectious Diseases (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used.
Results: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively.
Conclusion: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19.
Idioma: Inglés
DOI: 10.1007/s10096-020-04139-5
Año: 2021
Publicado en: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 40 (2021), 1343–1349
ISSN: 0934-9723
Factor impacto JCR: 5.103 (2021)
Categ. JCR: MICROBIOLOGY rank: 49 / 138 = 0.355 (2021) - Q2 - T2
Categ. JCR: INFECTIOUS DISEASES rank: 41 / 96 = 0.427 (2021) - Q2 - T2
Factor impacto CITESCORE: 6.7 - Medicine (Q1)
Factor impacto SCIMAGO: 1.205 - Medicine (miscellaneous) (Q1) - Infectious Diseases (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2023-05-18-14:03:17)
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Record created 2021-03-10, last modified 2023-05-19