Screening of severe acute respiratory syndrome coronavirus-2 infection during labor and delivery using polymerase chain reaction and immunoglobulin testing
Saviron-Cornudella, Ricardo (Universidad de Zaragoza) ; Villalba, Ana ; Esteban, Luis M ; Tajada, Mauricio (Universidad de Zaragoza) ; Rodríguez-Solanilla, Belén ; Andeyro-Garcia, Mercedes ; Zapardiel, Javier ; Rite, Segundo ; Castan-Larraz, Berta ; Pérez-López, Faustino
Resumen: Aims
To assess severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during labor and delivery with polymerase chain reaction (PCR) and using immunoglobulin G and M testing to correlate with maternal and perinatal outcomes.
Main methods
Pregnant women admitted for labor and delivery at two Spanish hospitals were screened for SARS-CoV-2 infection by PCR test and by detection of serum immunoglobulins G and M. Maternal and perinatal outcomes were compared in women with laboratory evidence of SARS-CoV-2 infection with those with negative tests.
Key findings
Between March 31st and September 30th, 2020, 1211 pregnant women were screened for SARS-CoV-2 infection. The prevalence of laboratory evidence of SARS-CoV-2 infections was 5.4% (n = 65), corresponding to (i) 22 ongoing infections at admission, including two with mild clinical symptoms and 20 asymptomatic women; (ii) 43 cases of previous SARS-CoV-2 exposure; (iii) and 1146 women who were negative for both SARS-CoV-2 PCR and serological test. None of the screened mothers required hospital admission for coronavirus disease before or after delivery, nor were any of the newborns admitted to the intensive care unit. All newborns from mothers with positive PCR on admission were PCR negative. There were no significant differences in maternal or perinatal outcomes among the three studied groups.
Significance
Ongoing or previous SARS-CoV-2 infection with asymptomatic or mild clinical symptoms detected during screening in pregnant women at labor and delivery do not have a higher rate of adverse maternal or perinatal outcomes.
Idioma: Inglés
DOI: 10.1016/j.lfs.2021.119200
Año: 2021
Publicado en: LIFE SCIENCES 271, 119200 (2021), j.lfs.2021.119200 [7 pp.]
ISSN: 0024-3205
Factor impacto JCR: 6.78 (2021)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 36 / 279 = 0.129 (2021) - Q1 - T1
Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 33 / 140 = 0.236 (2021) - Q1 - T1
Factor impacto CITESCORE: 8.0 - Biochemistry, Genetics and Molecular Biology (Q1) - Pharmacology, Toxicology and Pharmaceutics (Q1) - Medicine (Q1)
Factor impacto SCIMAGO: 1.132 - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)
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Exportado de SIDERAL (2023-05-18-13:47:44)
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To assess severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during labor and delivery with polymerase chain reaction (PCR) and using immunoglobulin G and M testing to correlate with maternal and perinatal outcomes.
Main methods
Pregnant women admitted for labor and delivery at two Spanish hospitals were screened for SARS-CoV-2 infection by PCR test and by detection of serum immunoglobulins G and M. Maternal and perinatal outcomes were compared in women with laboratory evidence of SARS-CoV-2 infection with those with negative tests.
Key findings
Between March 31st and September 30th, 2020, 1211 pregnant women were screened for SARS-CoV-2 infection. The prevalence of laboratory evidence of SARS-CoV-2 infections was 5.4% (n = 65), corresponding to (i) 22 ongoing infections at admission, including two with mild clinical symptoms and 20 asymptomatic women; (ii) 43 cases of previous SARS-CoV-2 exposure; (iii) and 1146 women who were negative for both SARS-CoV-2 PCR and serological test. None of the screened mothers required hospital admission for coronavirus disease before or after delivery, nor were any of the newborns admitted to the intensive care unit. All newborns from mothers with positive PCR on admission were PCR negative. There were no significant differences in maternal or perinatal outcomes among the three studied groups.
Significance
Ongoing or previous SARS-CoV-2 infection with asymptomatic or mild clinical symptoms detected during screening in pregnant women at labor and delivery do not have a higher rate of adverse maternal or perinatal outcomes.
Idioma: Inglés
DOI: 10.1016/j.lfs.2021.119200
Año: 2021
Publicado en: LIFE SCIENCES 271, 119200 (2021), j.lfs.2021.119200 [7 pp.]
ISSN: 0024-3205
Factor impacto JCR: 6.78 (2021)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 36 / 279 = 0.129 (2021) - Q1 - T1
Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 33 / 140 = 0.236 (2021) - Q1 - T1
Factor impacto CITESCORE: 8.0 - Biochemistry, Genetics and Molecular Biology (Q1) - Pharmacology, Toxicology and Pharmaceutics (Q1) - Medicine (Q1)
Factor impacto SCIMAGO: 1.132 - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Exportado de SIDERAL (2023-05-18-13:47:44)
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Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Anatomía y Embriología Humana
Artículos > Artículos por área > Obstetricia y Ginecología
Registro creado el 2021-04-12, última modificación el 2023-05-19