Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications

Idiago López, J. ; Moreno Antolín, E. ; Fuente, J.M. de la ; Fratila, R.M.

Resumen: Bioorthogonal chemistry comprises chemical reactions that can take place inside complex biological environments, providing outstanding tools for the investigation and elucidation of biological processes. Its use in combination with nanotechnology can lead to further developments in diverse areas of biomedicine, such as molecular bioimaging, targeted delivery, in situdrug activation, study of cell-nanomaterial interactions, biosensing, etc.Here, we summarise the recent efforts to bring together the unique properties of nanoparticles and the remarkable features of bioorthogonal reactions to create a toolbox of new or improved biomedical applications. We show how, by joining forces, bioorthogonal chemistry and nanotechnology can overcome some of the key current limitations in the field of nanomedicine, providing better, faster and more sensitive nanoparticle-based bioimaging and biosensing techniques, as well as therapeutic nanoplatforms with superior efficacy.

Idioma: Inglés

DOI: 10.1039/d0na00873g

Año: 2021

Publicado en: Nanoscale Advances 3, 5 (2021), 1261-1292
ISSN: 2516-0230

Factor impacto JCR: 5.598 (2021)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 56 / 180 = 0.311 (2021) - Q2 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 111 / 345 = 0.322 (2021) - Q2 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 55 / 109 = 0.505 (2021) - Q3 - T2

Factor impacto CITESCORE: 5.7 - Engineering (Q1) - Materials Science (Q1) - Physics and Astronomy (Q1) - Chemical Engineering (Q2)

Factor impacto SCIMAGO: 1.043 - Atomic and Molecular Physics, and Optics (Q1) - Materials Science (miscellaneous) (Q1) - Engineering (miscellaneous) (Q1) - Bioengineering (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg
Financiación: info:eu-repo/grantAgreement/ES/MECD/FPU17-02024
Financiación: info:eu-repo/grantAgreement/EUR/M-ERA.NET/COFUND-MagicCellGene-PCIN-2017-060
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BIO2017-84246-C2-1-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PGC2018-096016-B-I00
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640

Tipo y forma: Revisión (Versión definitiva)