Classical and atypical scrapie in sheep and goats: Review on the etiology, genetic factors, pathogenesis, diagnosis, and control measures of both diseases

Acín, Cristina (Universidad de Zaragoza) ; Bolea, Rosa (Universidad de Zaragoza) ; Monzón, Marta (Universidad de Zaragoza) ; Monleón, Eva (Universidad de Zaragoza) ; Moreno, Bernardino (Universidad de Zaragoza) ; Filali, Hicham ; Marín, Belén (Universidad de Zaragoza) ; Sola, Diego (Universidad de Zaragoza) ; Betancor, Marina (Universidad de Zaragoza) ; Guijarro, Isabel M. ; García, Mirta (Universidad de Zaragoza) ; Vargas, Antonio ; Badiola, Juan José (Universidad de Zaragoza)

Resumen: Prion diseases, such as scrapie, are neurodegenerative diseases with a fatal outcome, caused by a conformational change of the cellular prion protein (PrPC), originating with the pathogenic form (PrPSc). Classical scrapie in small ruminants is the paradigm of prion diseases, as it was the first transmissible spongiform encephalopathy (TSE) described and is the most studied. It is necessary to understand the etiological properties, the relevance of the transmission pathways, the infectivity of the tissues, and how we can improve the detection of the prion protein to encourage detection of the disease. The aim of this review is to perform an overview of classical and atypical scrapie disease in sheep and goats, detailing those special issues of the disease, such as genetic fac-tors, diagnostic procedures, and surveillance approaches carried out in the European Union with the objective of controlling the dissemination of scrapie disease.

Idioma: Inglés

DOI: 10.3390/ani11030691

Año: 2021

Publicado en: Animals 11, 3 (2021), 691 [20 pp.]
ISSN: 2076-2615

Factor impacto JCR: 3.231 (2021)

Categ. JCR: VETERINARY SCIENCES rank: 16 / 145 = 0.11 (2021) - Q1 - T1
Categ. JCR: AGRICULTURE, DAIRY & ANIMAL SCIENCE rank: 13 / 63 = 0.206 (2021) - Q1 - T1

Factor impacto CITESCORE: 2.7 - Veterinary (Q2) - Agricultural and Biological Sciences (Q2)

Factor impacto SCIMAGO: 0.61 - Veterinary (miscellaneous) (Q1) - Animal Science and Zoology (Q1)

Tipo y forma: Revisión (Versión definitiva)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)