Pesticide exposure and gender discrepancy in breast cancer

Ledda, C. ; Bracci, M. ; Lovreglio, P ; Senia, P. ; Larrosa, M. ; Martínez-Jarreta, María Begoña (Universidad de Zaragoza) ; Rapisarda, V.

Resumen: OBJECTIVE: It is biologically plausible that occupational and environmental pesticide exposure may contribute to breast cancer risk. Persistent chemical compounds, such as pesticides, tend to be lipophilic and are detected in human breast milk and adipose tissue. Therefore, the present systematic review ims to clarify the gender difference in breast cancer concerning pesticide exposure.MATERIALS AND METHODS: A total of 70 studies satisfied the inclusion criteria and were included in the systematic review. RESULTS: From the studies analyzed, it was observed that exposure to pesticides could be a risk factor for breast cancer in women, in particular in young women and in women who experienced menarche at a young age. In contrast, no association was found for breast cancer in men. Female breast cancer is correlated with estrogen receptor-negative tumor characteristics. Breast cancer in men was no correlated with pesticide exposure. CONCLUSIONS: Breast cancer in women has been linked to estrogen receptor positivity, but this positivity appears to be inversely related to fertility. The estrogen-like effects of organochlorine
pesticides could be the cause of the observed gender differences.

Idioma: Inglés

DOI: 10.26355/eurrev_202104_25543

Año: 2021

Publicado en: European Review for Medical and Pharmacological Sciences 25, 7 (2021), 2898-2915
ISSN: 1128-3602

Factor impacto JCR: 3.784 (2021)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 125 / 279 = 0.448 (2021) - Q2 - T2

Factor impacto CITESCORE: 6.0 - Medicine (Q1)

Factor impacto SCIMAGO: 0.658 - Pharmacology (medical) (Q2) - Medicine (miscellaneous) (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Medicina Legal y Forense (Dpto. Farmac.Fisiol.y Med.L.F.)