Effects of daily melatonin supplementation on visual loss, circadian rhythms, and hepatic oxidative damage in a rodent model of retinitis pigmentosa

Fuentes-Broto, Lorena (Universidad de Zaragoza) ; Perdices, Lorena ; Segura, Francisco (Universidad de Zaragoza) ; Orduna-Hospital, Elvira (Universidad de Zaragoza) ; Insa-Sánchez, Gema (Universidad de Zaragoza) ; Sánchez-Cano, Ana I. ; Cuenca, Nicolás ; Pinilla, Isabel

Resumen: Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mgkg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats.

Idioma: Inglés

DOI: 10.3390/antiox10111853

Año: 2021

Publicado en: Antioxidants 10, 11 (2021), 1853 [16 pp]
ISSN: 2076-3921

Factor impacto JCR: 7.675 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 50 / 297 = 0.168 (2021) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 12 / 144 = 0.083 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, MEDICINAL rank: 4 / 63 = 0.063 (2021) - Q1 - T1

Factor impacto CITESCORE: 6.5 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.008 - Biochemistry (Q1) - Physiology (Q1) - Molecular Biology (Q1) - Clinical Biochemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B08-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)