Antibody-based immunotoxins for colorectal cancer therapy

Sanz, L. ; Ibáñez-Pérez, R. (Universidad de Zaragoza) ; Guerrero-Ochoa, P. (Universidad de Zaragoza) ; Lacadena, J. ; Anel, A. (Universidad de Zaragoza)

Resumen: Monoclonal antibodies (mAbs) are included among the treatment options for advanced colorectal cancer (CRC). However, while these mAbs effectively target cancer cells, they may have limited clinical activity. A strategy to improve their therapeutic potential is arming them with a toxic payload. Immunotoxins (ITX) combining the cell-killing ability of a toxin with the specificity of a mAb constitute a promising strategy for CRC therapy. However, several important challenges in optimizing ITX remain, including suboptimal pharmacokinetics and especially the immunogenicity of the toxin moiety. Nonetheless, ongoing research is working to solve these limitations and expand CRC patients’ therapeutic armory. In this review, we provide a comprehensive overview of targets and toxins employed in the design of ITX for CRC and highlight a wide selection of ITX tested in CRC patients as well as preclinical candidates. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglés

DOI: 10.3390/biomedicines9111729

Año: 2021

Publicado en: Biomedicines 9, 11 (2021), 1729 [24 pp]
ISSN: 2227-9059

Factor impacto JCR: 4.757 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 121 / 297 = 0.407 (2021) - Q2 - T2
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 87 / 279 = 0.312 (2021) - Q2 - T1
Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 62 / 140 = 0.443 (2021) - Q2 - T2

Factor impacto CITESCORE: 3.0 - Medicine (Q2) - Biochemistry, Genetics and Molecular Biology (Q3)

Factor impacto SCIMAGO: 0.874 - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B31-20R

Tipo y forma: Article (Published version)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)