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> Magnetogenetics: remote activation of cellular functions triggered by magnetic switches
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Magnetogenetics: remote activation of cellular functions triggered by magnetic switches
Sol Fernández, S. del
;
Martínez Vicente, P.
;
Gomollón Zueco, P.
;
Castro Hinojosa, C.
;
Gutiérrez, L.
(Universidad de Zaragoza)
;
Fratila, R. M.
;
Moros, M.
Resumen:
During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to novel and exciting applications, both in basic research and clinical applications. Indeed, the use of physical and non-invasive stimuli such as light, electricity or magnetic fields offers the possibility of manipulating biological processes with spatial and temporal resolution in a remote fashion. The use of magnetic fields is especially appealing for in vivo applications because they can penetrate deep into tissues, as opposed to light. In combination with magnetic actuators they are emerging as a new instrument to precisely manipulate biological functions. This approach, coined as magnetogenetics, provides an exclusive tool to study how cells transform mechanical stimuli into biochemical signalling and offers the possibility of activating intracellular pathways connected to temperature-sensitive proteins. In this review we provide a critical overview of the recent developments in the field of magnetogenetics. We discuss general topics regarding the three main components for magnetic field-based actuation: the magnetic fields, the magnetic actuators and the cellular targets. We first introduce the main approaches in which the magnetic field can be used to manipulate the magnetic actuators, together with the most commonly used magnetic field configurations and the physicochemical parameters that can critically influence the magnetic properties of the actuators. Thereafter, we discuss relevant examples of magneto-mechanical and magneto-thermal stimulation, used to control stem cell fate, to activate neuronal functions, or to stimulate apoptotic pathways, among others. Finally, although magnetogenetics has raised high expectations from the research community, to date there are still many obstacles to be overcome in order for it to become a real alternative to optogenetics for instance. We discuss some controversial aspects related to the insufficient elucidation of the mechanisms of action of some magnetogenetics constructs and approaches, providing our opinion on important challenges in the field and possible directions for the upcoming years. © 2022 The Royal Society of Chemistry.
Idioma:
Inglés
DOI:
10.1039/d1nr06303k
Año:
2022
Publicado en:
Nanoscale
14, 6 (2022), 2091-2118
ISSN:
2040-3364
Factor impacto JCR:
6.7 (2022)
Categ. JCR:
MATERIALS SCIENCE, MULTIDISCIPLINARY
rank: 83 / 343 = 0.242
(2022)
- Q1
- T1
Categ. JCR:
PHYSICS, APPLIED
rank: 27 / 160 = 0.169
(2022)
- Q1
- T1
Categ. JCR:
CHEMISTRY, MULTIDISCIPLINARY
rank: 43 / 178 = 0.242
(2022)
- Q1
- T1
Categ. JCR:
NANOSCIENCE & NANOTECHNOLOGY
rank: 37 / 107 = 0.346
(2022)
- Q2
- T2
Factor impacto CITESCORE:
13.6 -
Materials Science
(Q1)
Factor impacto SCIMAGO:
1.62 -
Nanoscience and Nanotechnology
(Q1) -
Materials Science (miscellaneous)
(Q1)
Financiación:
info:eu-repo/grantAgreement/ES/DGA-FEDER/E15-17R
Financiación:
info:eu-repo/grantAgreement/EC/H2020/853468/EU/Remote control of cellular signalling triggered by magnetic switching/SIROCCO
Financiación:
info:eu-repo/grantAgreement/ES/MINECO/PGC2018-096016-B-I00
Financiación:
info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512
Financiación:
info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640
Financiación:
info:eu-repo/grantAgreement/ES/MINECO/RYC-2019-026860-I
Tipo y forma:
Artículo (Versión definitiva)
Área (Departamento):
Área Química Analítica
(
Dpto. Química Analítica
)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
Exportado de SIDERAL (2024-03-18-13:47:32)
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