Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy
Financiación H2020 / H2020 Funds
Resumen: Heterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pivotal regulatory role as antioxidant agent, dampening the harmful effects of intracellular reactive oxidative species (ROS). Herein, we present copper-iron oxide spinel nanoparticles that exhibit a versatile and selective catalytic response to reduce GSH levels while generating ROS in a cascade reaction. We demonstrate a clear correlation between GSH depletion and apoptotic cell death in tumor cells in the presence of the copper-iron nanocatalyst. Furthermore, we also provide a novel analytical protocol, alternative to state-of-the-art commercial kits, to accurately monitoring the concentration of GSH intracellular levels in both tumor and healthy cells. We observe a selective action of the nanoparticles, with lower toxicity in healthy cell lines, whose intrinsic GSH levels are lower, and intense apoptosis in tumor cells accompanied by a fast reduction of GSH levels.
Idioma: Inglés
DOI: 10.1016/j.jcis.2022.03.036
Año: 2022
Publicado en: Journal of Colloid and Interface Science 617 (2022), 704-717
ISSN: 0021-9797

Factor impacto JCR: 9.9 (2022)
Categ. JCR: CHEMISTRY, PHYSICAL rank: 29 / 161 = 0.18 (2022) - Q1 - T1
Factor impacto CITESCORE: 15.5 - Chemical Engineering (Q1) - Materials Science (Q1)

Factor impacto SCIMAGO: 1.604 - Biomaterials (Q1) - Surfaces, Coatings and Films (Q1) - Electronic, Optical and Magnetic Materials (Q1) - Colloid and Surface Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE
Tipo y forma: Article (Published version)
Área (Departamento): Área Estomatología (Dpto. Cirugía)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)


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