Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy

Christou, E. ; Pearson, J. R. ; Beltrán, A. M. ; Fernández-Afonso, Y. ; Gutiérrez, L. (Universidad de Zaragoza) ; de la Fuente, J. M. ; Gámez, F. ; García-Martín, M. L. ; Caro, C.

Resumen: The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed To-mography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM-1·s-1 ) and X-ray attenuation properties (8.8 HU mM-1·HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (¿T ˜ 2.5¿C) and Near-Infrared (NIR) light (¿T ˜ 17¿C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglés

DOI: 10.3390/pharmaceutics14030636

Año: 2022

Publicado en: Pharmaceutics 14, 3 (2022), 636 - [11 pp]
ISSN: 1999-4923

Factor impacto JCR: 5.4 (2022)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 50 / 278 = 0.18 (2022) - Q1 - T1

Factor impacto CITESCORE: 6.9 - Pharmacology, Toxicology and Pharmaceutics (Q1)

Factor impacto SCIMAGO: 0.795 - Pharmaceutical Science (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113108RB-I00/AEI/10.13039/50110001103
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-118448RB-C21
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-86655-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)