Decellularization of tumours: A new frontier in tissue engineering

García Gareta, E. (Universidad de Zaragoza) ; Pérez, M. Á. (Universidad de Zaragoza) ; García Aznar, J. M. (Universidad de Zaragoza)

Resumen: Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes.

Idioma: Inglés

DOI: 10.1177/20417314221091682

Año: 2022

Publicado en: Journal of Tissue Engineering 13 (2022), [16 pp.]
ISSN: 2041-7314

Factor impacto JCR: 8.2 (2022)

Categ. JCR: CELL & TISSUE ENGINEERING rank: 3 / 29 = 0.103 (2022) - Q1 - T1

Factor impacto CITESCORE: 9.9 - Engineering (Q1) - Medicine (Q1) - Materials Science (Q1)

Factor impacto SCIMAGO: 0.991 - Biomedical Engineering (Q1) - Medicine (miscellaneous) (Q1) - Biomaterials (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2020-113819RB-I00
Financiación: info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21

Tipo y forma: Review (Published version)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
Área (Departamento): Área Cienc.Mater. Ingen.Metal. (Dpto. Ciencia Tecnol.Mater.Fl.)