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Effects of ketosis on cocaine-induced reinstatement in male mice;
Ródenas-González, F.
;
Blanco-Gandía, M. C.
(Universidad de Zaragoza)
;
Miñarro, J.
;
Rodríguez-Arias, M.
Resumen:
In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate the rewarding effects of cocaine, but the negative metabolic consequences rule out the recommendation of using it as a complementary treatment. Thus, the main aim of this study was to evaluate the effects of the KD on cocaine conditioned place preference (CPP) during acquisition, extinction, and reinstatement. 41 OF1 male mice were employed to assess the effects of the KD on a 10 mg/kg cocaine-induced CPP. Animals were divided into three groups: SD, KD, and KD after the Post-Conditioning test. The results revealed that, while access to the KD did not block CPP acquisition, it did significantly reduce the number of sessions required to extinguish the drug-associated memories and it blocked the priming-induced reinstatement. © 2022 The Author(s)
Idioma:
Inglés
DOI:
10.1016/j.neulet.2022.136619
Año:
2022
Publicado en:
NEUROSCIENCE LETTERS
778 (2022), 136619 [6 pp]
ISSN:
0304-3940
Factor impacto JCR:
2.5 (2022)
Categ. JCR:
NEUROSCIENCES
rank: 198 / 272 = 0.728
(2022)
- Q3
- T3
Factor impacto CITESCORE:
5.9 -
Neuroscience
(Q2)
Factor impacto SCIMAGO:
0.802 -
Neuroscience (miscellaneous)
(Q2)
Financiación:
info:eu-repo/grantAgreement/ES/MICINN/PID2020-112672RB-100
Tipo y forma:
Article (Published version)
Área (Departamento):
Área Psicolog.Evolut.Educac
(
Dpto. Psicología y Sociología
)
Exportado de SIDERAL (2024-03-18-14:42:09)
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Notice créée le 2022-07-11, modifiée le 2024-03-19
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