The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response

Ayuso, J. M. ; Ochoa Garrido, I. (Universidad de Zaragoza)

Resumen: During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets. However, since the 2000s, we have seen a gradual shift in this paradigm with numerous studies highlighting the importance of the tumor microenvironment in tumor progression, patient prognosis, and therapy response. Solid tumors are highly complex systems where numerous cell types and microenvironmental factors are intertwined, potentially affecting tumor evolution, treatment response, and patient outcome. Stromal cells such as fibroblasts and immune cells can stimulate or suppress tumor growth and are currently being used as therapeutic targets in numerous studies and clinical trials...

Idioma: Inglés

DOI: 10.3390/cancers14081983

Año: 2022

Publicado en: Cancers 14, 8 (2022), 1983 [4 pp.]
ISSN: 2072-6694

Factor impacto JCR: 5.2 (2022)

Categ. JCR: ONCOLOGY rank: 72 / 241 = 0.299 (2022) - Q2 - T1

Factor impacto CITESCORE: 7.4 - Medicine (Q1) - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.312 - Oncology (Q1) - Cancer Research (Q2)

Tipo y forma: (Published version)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)