Dinuclear silver and gold bisNHC complexes as drug candidates for cancer therapy
Quintana, M. ; Rodriguez-Rius, A. ; Vellé, A. ; Vives, S. ; Sanz Miguel, P.J. (Universidad de Zaragoza) ; Triola, G.
Resumen: We report four dinuclear silver(I) and gold(I) complexes containing two different bidentate N-heterocyclic carbene ligands (bisNHC). One of these complexes 4, shows strong and selective anticancer activity against the human ovarian cancer cell line A2780. Mechanistically, 4 enhances the oxidative stress by stimulating reactive oxygen species production and inhibiting the scavenging activity of thioredoxin reductase. Our findings provide evidence that tuning ligand and electronic properties of metal-NHC complexes can modulate their reactivity and selectivity and it may result in potential novel anticancer drugs.
Idioma: Inglés
DOI: 10.1016/j.bmc.2022.116814
Año: 2022
Publicado en: Bioorganic and Medicinal Chemistry 67 (2022), 116814 [8 pp.]
ISSN: 0968-0896
Factor impacto JCR: 3.5 (2022)
Categ. JCR: CHEMISTRY, ORGANIC rank: 12 / 52 = 0.231 (2022) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 150 / 285 = 0.526 (2022) - Q3 - T2
Categ. JCR: CHEMISTRY, MEDICINAL rank: 32 / 60 = 0.533 (2022) - Q3 - T2
Factor impacto CITESCORE: 6.4 - Biochemistry, Genetics and Molecular Biology (Q2) - Chemistry (Q2) - Pharmacology, Toxicology and Pharmaceutics (Q2)
Factor impacto SCIMAGO: 0.573 - Organic Chemistry (Q2) - Clinical Biochemistry (Q2) - Drug Discovery (Q2) - Pharmaceutical Science (Q2) - Molecular Medicine (Q3) - Biochemistry (Q3) - Molecular Biology (Q3)
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E42-20R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096323-B-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Idioma: Inglés
DOI: 10.1016/j.bmc.2022.116814
Año: 2022
Publicado en: Bioorganic and Medicinal Chemistry 67 (2022), 116814 [8 pp.]
ISSN: 0968-0896
Factor impacto JCR: 3.5 (2022)
Categ. JCR: CHEMISTRY, ORGANIC rank: 12 / 52 = 0.231 (2022) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 150 / 285 = 0.526 (2022) - Q3 - T2
Categ. JCR: CHEMISTRY, MEDICINAL rank: 32 / 60 = 0.533 (2022) - Q3 - T2
Factor impacto CITESCORE: 6.4 - Biochemistry, Genetics and Molecular Biology (Q2) - Chemistry (Q2) - Pharmacology, Toxicology and Pharmaceutics (Q2)
Factor impacto SCIMAGO: 0.573 - Organic Chemistry (Q2) - Clinical Biochemistry (Q2) - Drug Discovery (Q2) - Pharmaceutical Science (Q2) - Molecular Medicine (Q3) - Biochemistry (Q3) - Molecular Biology (Q3)
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E42-20R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096323-B-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-03-18-13:26:30)
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Record created 2022-08-31, last modified 2024-03-19