Dinuclear silver and gold bisNHC complexes as drug candidates for cancer therapy

Quintana, M. ; Rodriguez-Rius, A. ; Vellé, A. ; Vives, S. ; Sanz Miguel, P.J. (Universidad de Zaragoza) ; Triola, G.

Resumen: We report four dinuclear silver(I) and gold(I) complexes containing two different bidentate N-heterocyclic carbene ligands (bisNHC). One of these complexes 4, shows strong and selective anticancer activity against the human ovarian cancer cell line A2780. Mechanistically, 4 enhances the oxidative stress by stimulating reactive oxygen species production and inhibiting the scavenging activity of thioredoxin reductase. Our findings provide evidence that tuning ligand and electronic properties of metal-NHC complexes can modulate their reactivity and selectivity and it may result in potential novel anticancer drugs.

Idioma: Inglés

DOI: 10.1016/j.bmc.2022.116814

Año: 2022

Publicado en: Bioorganic and Medicinal Chemistry 67 (2022), 116814 [8 pp.]
ISSN: 0968-0896

Factor impacto JCR: 3.5 (2022)

Categ. JCR: CHEMISTRY, ORGANIC rank: 12 / 52 = 0.231 (2022) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 150 / 285 = 0.526 (2022) - Q3 - T2
Categ. JCR: CHEMISTRY, MEDICINAL rank: 32 / 60 = 0.533 (2022) - Q3 - T2

Factor impacto CITESCORE: 6.4 - Biochemistry, Genetics and Molecular Biology (Q2) - Chemistry (Q2) - Pharmacology, Toxicology and Pharmaceutics (Q2)

Factor impacto SCIMAGO: 0.573 - Organic Chemistry (Q2) - Clinical Biochemistry (Q2) - Drug Discovery (Q2) - Pharmaceutical Science (Q2) - Molecular Medicine (Q3) - Biochemistry (Q3) - Molecular Biology (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E42-20R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096323-B-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)