Nanoengineering palladium plasmonic nanosheets inside polymer nanospheres for photothermal therapy and targeted drug delivery

Uson, L. ; Yus, C. (Universidad de Zaragoza) ; Mendoza, G. ; Leroy, E. ; Irusta, S. (Universidad de Zaragoza) ; Alejo, T. (Universidad de Zaragoza) ; García-Domingo, D. ; Larrea, A. ; Arruebo, M. (Universidad de Zaragoza) ; Arenal, R. ; Sebastián, V. (Universidad de Zaragoza)

Resumen: The incorporation of plasmonic nanoconstructs in biodegradable polymeric nanoparticles (NPs), together with therapeutic drugs in a controlled procedure is of interest for different applications in Nanomedicine. Advanced hybrid nanomaterials can be engineered by combining the in situ formation of plasmonic palladium nanosheets (NSs) and the proper ionic nature of the encapsulated drug. This study presents a new procedure to synthesize hybrid nanostructures by a Pickering double emulsion. Anisotropic palladium (Pd) NSs with unique near-infrared (NIR)-optical properties can be assembled within a poly lactic-co-glycolic acid matrix of < 200 nm NPs, when Pd precursors are in situ reduced via a gas-phase procedure. The hybrid nanomaterials respond to external NIR light stimulus. The unprecedented precision to assemble, in a single stage, plasmonic nanoconstructs having a total loading selectivity, when encapsulated in combination with hydrophobic drugs, offers new opportunities in the new class of theragnostics, in particular when triggered drug delivery and photothermal therapies are required.

Idioma: Inglés

DOI: 10.1002/adfm.202106932

Año: 2022

Publicado en: Advanced Functional Materials 32, 9 (2022), 2106932 [14 pp.]
ISSN: 1616-301X

Factor impacto JCR: 19.0 (2022)

Categ. JCR: CHEMISTRY, PHYSICAL rank: 10 / 161 = 0.062 (2022) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 16 / 343 = 0.047 (2022) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 9 / 107 = 0.084 (2022) - Q1 - T1
Categ. JCR: PHYSICS, CONDENSED MATTER rank: 6 / 67 = 0.09 (2022) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 8 / 178 = 0.045 (2022) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 8 / 160 = 0.05 (2022) - Q1 - T1

Factor impacto CITESCORE: 27.9 - Materials Science (Q1) - Chemistry (Q1) - Physics and Astronomy (Q1)

Factor impacto SCIMAGO: 5.565 - Biomaterials (Q1) - Chemistry (miscellaneous) (Q1) - Condensed Matter Physics (Q1) - Nanoscience and Nanotechnology (Q1) - Electronic, Optical and Magnetic Materials (Q1) - Materials Science (miscellaneous) (Q1) - Electrochemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E13-20R
Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Financiación: info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2019-104739GB-I00/AEI-10.13039-501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)