Engineered protein-driven synthesis of tunable iron oxide nanoparticles as T1 and T2 magnetic resonance imaging contrast agents
Aires, Antonio ; Fernández-Afonso, Yilian ; Guedes, Gabriela ; Guisasola, Eduardo ; Gutiérrez, Lucía (Universidad de Zaragoza) ; Cortajarena, Aitziber L.
Resumen: Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications.
Idioma: Inglés
DOI: 10.1021/acs.chemmater.2c01746
Año: 2022
Publicado en: Chemistry of materials 34, 24 (2022), 10832-10841
ISSN: 0897-4756
Factor impacto JCR: 8.6 (2022)
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 63 / 343 = 0.184 (2022) - Q1 - T1
Categ. JCR: CHEMISTRY, PHYSICAL rank: 38 / 161 = 0.236 (2022) - Q1 - T1
Factor impacto CITESCORE: 15.9 - Materials Science (Q1) - Chemistry (Q1) - Chemical Engineering (Q1)
Factor impacto SCIMAGO: 2.869 - Chemical Engineering (miscellaneous) (Q1) - Materials Chemistry (Q1) - Chemistry (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-111649RB-I00
Financiación: info:eu-repo/grantAgreement/EC/H2020/101069356 /EU/Nano-Biological Contrast Agent Platform for MRI Imaging/Nano-imaging
Financiación: info:eu-repo/grantAgreement/EC/H2020/648071/EU/Protein-based functional nanostructures/ProNANO
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MDM-2017-0720
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Idioma: Inglés
DOI: 10.1021/acs.chemmater.2c01746
Año: 2022
Publicado en: Chemistry of materials 34, 24 (2022), 10832-10841
ISSN: 0897-4756
Factor impacto JCR: 8.6 (2022)
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 63 / 343 = 0.184 (2022) - Q1 - T1
Categ. JCR: CHEMISTRY, PHYSICAL rank: 38 / 161 = 0.236 (2022) - Q1 - T1
Factor impacto CITESCORE: 15.9 - Materials Science (Q1) - Chemistry (Q1) - Chemical Engineering (Q1)
Factor impacto SCIMAGO: 2.869 - Chemical Engineering (miscellaneous) (Q1) - Materials Chemistry (Q1) - Chemistry (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-111649RB-I00
Financiación: info:eu-repo/grantAgreement/EC/H2020/101069356 /EU/Nano-Biological Contrast Agent Platform for MRI Imaging/Nano-imaging
Financiación: info:eu-repo/grantAgreement/EC/H2020/648071/EU/Protein-based functional nanostructures/ProNANO
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MDM-2017-0720
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-03-18-17:02:10)
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Record created 2023-02-24, last modified 2024-03-19