Engineered protein-driven synthesis of tunable iron oxide nanoparticles as T1 and T2 magnetic resonance imaging contrast agents

Aires, Antonio ; Fernández-Afonso, Yilian ; Guedes, Gabriela ; Guisasola, Eduardo ; Gutiérrez, Lucía (Universidad de Zaragoza) ; Cortajarena, Aitziber L.

Resumen: Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications.

Idioma: Inglés

DOI: 10.1021/acs.chemmater.2c01746

Año: 2022

Publicado en: Chemistry of materials 34, 24 (2022), 10832-10841
ISSN: 0897-4756

Factor impacto JCR: 8.6 (2022)

Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 63 / 343 = 0.184 (2022) - Q1 - T1
Categ. JCR: CHEMISTRY, PHYSICAL rank: 38 / 161 = 0.236 (2022) - Q1 - T1

Factor impacto CITESCORE: 15.9 - Materials Science (Q1) - Chemistry (Q1) - Chemical Engineering (Q1)

Factor impacto SCIMAGO: 2.869 - Chemical Engineering (miscellaneous) (Q1) - Materials Chemistry (Q1) - Chemistry (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-111649RB-I00
Financiación: info:eu-repo/grantAgreement/EC/H2020/101069356 /EU/Nano-Biological Contrast Agent Platform for MRI Imaging/Nano-imaging
Financiación: info:eu-repo/grantAgreement/EC/H2020/648071/EU/Protein-based functional nanostructures/ProNANO
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MDM-2017-0720
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096016-B-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)