Silver-based terpyridine complexes as antitumor agents

Gil-Moles, María ; Olmos, M. Elena ; Monge, Miguel ; Beltrán-Visiedo, Manuel (Universidad de Zaragoza) ; Marzo, Isabel (Universidad de Zaragoza) ; López-de-Luzuriaga, José M. ; Gimeno, M. Concepción

Resumen: Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT-DNA binding and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy Lymphocytes T for some of these compounds. The CT-DNA interaction study has shown that these derivatives are be able to interact with CT-DNA via moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis via mitochondrial pathway.

Idioma: Inglés

DOI: 10.1002/chem.202300116

Año: 2023

Publicado en: Chemistry - A European Journal 29, 37 (2023), e202300116 [12 pp.]
ISSN: 0947-6539

Factor impacto JCR: 3.9 (2023)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 80 / 231 = 0.346 (2023) - Q2 - T2

Factor impacto CITESCORE: 7.9 - Organic Chemistry (Q1) - Catalysis (Q2)

Factor impacto SCIMAGO: 1.058 - Chemistry (miscellaneous) (Q1) - Organic Chemistry (Q1) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-104379RB-C22
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21

Tipo y forma: Article (Published version)

Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)