Antibacterial properties of phosphine gold(i) complexes with 5-fluorouracil

Ferrando, Ricardo ; Mitchell, Scott G. ; Atrián-Blasco, Elena ; Cerrada, Elena (Universidad de Zaragoza)

Resumen: New gold(I) complexes with coordination to 5-fluorouracil (5-FU), an anticancer drug with antibacterial properties, have been synthesised and characterised, and are the first reported examples of 5-FU–Au compounds. These new complexes show high solution stability, even in the presence of a cysteine derivative, and so were evaluated as antibacterial compounds against model Gram-positive and Gram-negative bacteria. All the complexes show excellent antibacterial activity against Gram-positive B. subtilis, most of them improving the activity of 5-FU alone. Furthermore, these new complexes are also active against Gram-negative E. coli, where [Au(5-FU)(PTA)], the complex with the smallest phosphane, is the most bactericidal, 32 times more active than 5-FU on its own.

Idioma: Inglés

DOI: 10.1039/d3dt01159c

Año: 2023

Publicado en: Dalton Transactions 52, 30 (2023), 10507-10514
ISSN: 1477-9226

Factor impacto JCR: 3.5 (2023)

Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 13 / 44 = 0.295 (2023) - Q2 - T1

Factor impacto CITESCORE: 6.6 - Inorganic Chemistry (Q2)

Factor impacto SCIMAGO: 0.697 - Inorganic Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21
Financiación: info:eu-repo/grantAgreement/ES/CSIC/MSCA-IF-ERC
Financiación: info:eu-repo/grantAgreement/EC/H2020/845427/EU/Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials/PePiPOM
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)