Antibacterial properties of phosphine gold(i) complexes with 5-fluorouracil
Ferrando, Ricardo ; Mitchell, Scott G. ; Atrián-Blasco, Elena ; Cerrada, Elena (Universidad de Zaragoza)
Resumen: New gold(I) complexes with coordination to 5-fluorouracil (5-FU), an anticancer drug with antibacterial properties, have been synthesised and characterised, and are the first reported examples of 5-FU–Au compounds. These new complexes show high solution stability, even in the presence of a cysteine derivative, and so were evaluated as antibacterial compounds against model Gram-positive and Gram-negative bacteria. All the complexes show excellent antibacterial activity against Gram-positive B. subtilis, most of them improving the activity of 5-FU alone. Furthermore, these new complexes are also active against Gram-negative E. coli, where [Au(5-FU)(PTA)], the complex with the smallest phosphane, is the most bactericidal, 32 times more active than 5-FU on its own.
Idioma: Inglés
DOI: 10.1039/d3dt01159c
Año: 2023
Publicado en: Dalton Transactions 52, 30 (2023), 10507-10514
ISSN: 1477-9226
Factor impacto JCR: 3.5 (2023)
Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 13 / 44 = 0.295 (2023) - Q2 - T1
Factor impacto CITESCORE: 6.6 - Inorganic Chemistry (Q2)
Factor impacto SCIMAGO: 0.697 - Inorganic Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21
Financiación: info:eu-repo/grantAgreement/ES/CSIC/MSCA-IF-ERC
Financiación: info:eu-repo/grantAgreement/EC/H2020/845427/EU/Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials/PePiPOM
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-11-22-12:10:18)
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Idioma: Inglés
DOI: 10.1039/d3dt01159c
Año: 2023
Publicado en: Dalton Transactions 52, 30 (2023), 10507-10514
ISSN: 1477-9226
Factor impacto JCR: 3.5 (2023)
Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 13 / 44 = 0.295 (2023) - Q2 - T1
Factor impacto CITESCORE: 6.6 - Inorganic Chemistry (Q2)
Factor impacto SCIMAGO: 0.697 - Inorganic Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21
Financiación: info:eu-repo/grantAgreement/ES/CSIC/MSCA-IF-ERC
Financiación: info:eu-repo/grantAgreement/EC/H2020/845427/EU/Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials/PePiPOM
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-11-22-12:10:18)
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Record created 2023-10-06, last modified 2024-11-25