Histological Evaluation of the Effect of Alendronate on the Maxillary Bone of Wistar Rats Combined with Orthodontic Movement of Intense Force
Cintora-López, Patricia ; Rojo, Rosa ; Pastor-Oliver, Cristina ; White, Ana
Resumen: To evaluate the histological adverse effects of alendronate administered systemically and topically in combination with orthodontic movement by intense force. Thirty-six 24-week-old female Wistar rats, ovariectomized, were used and divided into three groups (n = 12/group): control, locally treated with saline (0.07 ml/kg/week) (group 1) and experimental, treated with alendronic acid systemically (0.07 mg/kg/week) (group 2) and locally (7 mg/kg/week) (group 3). At 14 days, an orthodontic anchor was installed in the right first molar, and a force of 144 cN was applied for 28 days. The samples were processed for histological evaluation. Descriptive statistics, Shapiro-Wilk tests, one-way ANOVA with Bonferroni correction, one-way repeated measures ANOVA and chi-square tests were performed. All tests were statistically significant at p <0.05. The adverse events found in all groups were inflammation and osteoclastic activity. In the bisphosphonate-treated groups, there were statistically significant differences (p = 0.005) in the osteoclastic activity between the two hemiarcates. All rats in group 2 presented paralytic ileus. Compared to local administration, systemic treatment with alendronic acid produces more adverse effects, such as inflammation, fibrinoid necrosis, and osteoclastic activity. During the application of intense forces, it was not possible to show that there is necrosis associated with bisphosphonates.
Idioma: Inglés
DOI: 10.4067/S0717-95022023000300901
Año: 2023
Publicado en: INTERNATIONAL JOURNAL OF MORPHOLOGY 41, 3 (2023), 901-909
ISSN: 0717-9367
Factor impacto JCR: 0.4 (2023)
Categ. JCR: ANATOMY & MORPHOLOGY rank: 20 / 22 = 0.909 (2023) - Q4 - T3
Factor impacto CITESCORE: 0.9 - Anatomy (Q3)
Factor impacto SCIMAGO: 0.191 - Anatomy (Q3)
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-11-22-12:03:50)
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Idioma: Inglés
DOI: 10.4067/S0717-95022023000300901
Año: 2023
Publicado en: INTERNATIONAL JOURNAL OF MORPHOLOGY 41, 3 (2023), 901-909
ISSN: 0717-9367
Factor impacto JCR: 0.4 (2023)
Categ. JCR: ANATOMY & MORPHOLOGY rank: 20 / 22 = 0.909 (2023) - Q4 - T3
Factor impacto CITESCORE: 0.9 - Anatomy (Q3)
Factor impacto SCIMAGO: 0.191 - Anatomy (Q3)
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-11-22-12:03:50)
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Record created 2023-10-23, last modified 2024-11-25