Diagnosis in Scrapie: Conventional Methods and New Biomarkers

Sola, Diego (Universidad de Zaragoza) ; Betancor, Marina (Universidad de Zaragoza) ; Marco Lorente, Paula A. (Universidad de Zaragoza) ; Pérez Lázaro, Sonia (Universidad de Zaragoza) ; Barrio, Tomás ; Sevilla, Eloisa (Universidad de Zaragoza) ; Marín, Belén (Universidad de Zaragoza) ; Moreno, Bernardino (Universidad de Zaragoza) ; Monzón, Marta (Universidad de Zaragoza) ; Acín, Cristina (Universidad de Zaragoza) ; Bolea, Rosa (Universidad de Zaragoza) ; Badiola, Juan J. (Universidad de Zaragoza) ; Otero, Alicia (Universidad de Zaragoza)

Resumen: Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases.

Idioma: Inglés

DOI: 10.3390/pathogens12121399

Año: 2023

Publicado en: Pathogens 12, 12 (2023), 1399 [15 pp.]
ISSN: 2076-0817

Factor impacto JCR: 3.3 (2023)

Categ. JCR: MICROBIOLOGY rank: 70 / 161 = 0.435 (2023) - Q2 - T2

Factor impacto SCIMAGO: 0.843 - Immunology and Allergy (Q2) - Immunology and Microbiology (miscellaneous) (Q2) - Molecular Biology (Q2) - Microbiology (medical) (Q2) - Infectious Diseases (Q2)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)