Read-through therapy for mitochondrial DNA nonsense mutations

Pacheu-Grau,D. (Universidad de Zaragoza) ; Gómez-Durán,A. (Universidad de Zaragoza) ; López-Gallardo,E. (Universidad de Zaragoza) ; Montoya,J. (Universidad de Zaragoza) ; Ruiz-Pesini,E. (Universidad de Zaragoza)

Resumen: Disorders resulting from mitochondrial DNA (mtDNA) mutations, including nonsense mutations, do not yet have causal treatments. As we discuss here, read-through therapies appear to be a promising approach to the treatment of disorders arising from nuclear DNA (nDNA) nonsense mutations. The genetics of mitochondrial DNA suggest that this therapy will also be successful in the treatment of mitochondriopathies.

Idioma: Inglés

DOI: 10.1016/j.drudis.2012.04.012

Año: 2012

Publicado en: DRUG DISCOVERY TODAY 17, 19-20 (2012), 1063-1067
ISSN: 1359-6446

Factor impacto JCR: 6.551 (2012)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 12 / 259 = 0.046 (2012) - Q1 - T1

Tipo y forma: Article (Published version)

Área (Departamento): Área Inmunología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Proy. investigación DEA (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)