Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray

Arauzo, Beatriz (Universidad de Zaragoza) ; Lobera, M. Pilar (Universidad de Zaragoza) ; Monzon, Antonio (Universidad de Zaragoza) ; Santamaria, Jesús (Universidad de Zaragoza)

Resumen: Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 +/- 248.5 nm and 501.1 +/- 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa.

Idioma: Inglés

DOI: 10.1016/j.carbpol.2021.118543

Año: 2021

Publicado en: CARBOHYDRATE POLYMERS 273 (2021), 118543 [8 pp.]
ISSN: 0144-8617

Factor impacto JCR: 10.723 (2021)

Categ. JCR: CHEMISTRY, APPLIED rank: 4 / 72 = 0.056 (2021) - Q1 - T1
Categ. JCR: POLYMER SCIENCE rank: 3 / 90 = 0.033 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, ORGANIC rank: 2 / 56 = 0.036 (2021) - Q1 - T1

Factor impacto CITESCORE: 16.0 - Materials Science (Q1)

Factor impacto SCIMAGO: 1.612 - Organic Chemistry (Q1) - Materials Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)