Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray
Arauzo, Beatriz (Universidad de Zaragoza) ; Lobera, M. Pilar (Universidad de Zaragoza) ; Monzon, Antonio (Universidad de Zaragoza) ; Santamaria, Jesús (Universidad de Zaragoza)
Resumen: Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 +/- 248.5 nm and 501.1 +/- 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa.
Idioma: Inglés
DOI: 10.1016/j.carbpol.2021.118543
Año: 2021
Publicado en: CARBOHYDRATE POLYMERS 273 (2021), 118543 [8 pp.]
ISSN: 0144-8617
Factor impacto JCR: 10.723 (2021)
Categ. JCR: CHEMISTRY, APPLIED rank: 4 / 72 = 0.056 (2021) - Q1 - T1
Categ. JCR: POLYMER SCIENCE rank: 3 / 90 = 0.033 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, ORGANIC rank: 2 / 56 = 0.036 (2021) - Q1 - T1
Factor impacto CITESCORE: 16.0 - Materials Science (Q1)
Factor impacto SCIMAGO: 1.612 - Organic Chemistry (Q1) - Materials Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Idioma: Inglés
DOI: 10.1016/j.carbpol.2021.118543
Año: 2021
Publicado en: CARBOHYDRATE POLYMERS 273 (2021), 118543 [8 pp.]
ISSN: 0144-8617
Factor impacto JCR: 10.723 (2021)
Categ. JCR: CHEMISTRY, APPLIED rank: 4 / 72 = 0.056 (2021) - Q1 - T1
Categ. JCR: POLYMER SCIENCE rank: 3 / 90 = 0.033 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, ORGANIC rank: 2 / 56 = 0.036 (2021) - Q1 - T1
Factor impacto CITESCORE: 16.0 - Materials Science (Q1)
Factor impacto SCIMAGO: 1.612 - Organic Chemistry (Q1) - Materials Chemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-02-19-13:51:50)
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Record created 2024-02-12, last modified 2024-02-19