Association of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women

García-Alfaro, Pascual ; García, Sandra ; Rodriguez, Ignacio ; Pascual, Maria Angela ; Pérez-López, Faustino R.

Resumen: Aim: The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women. Materials and Methods: This was a cross-sectional study of 798 postmenopausal women aged 47-85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, 4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables. Results: Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: -0.02, 95% confidence interval [CI]: -0.03 - 0.00), and PTH with femoral neck BMD (β: -0.01, 95% CI: -0.02 - 0.01) and total hip BMD (β: -0.01, 95% CI: -0.01 - 0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01-1.03) and PTH (OR: 1.02, 95% CI: 1.01-1.04). Conclusions: Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD. © 2023 Journal of Mid-life Health.

Idioma: Inglés

DOI: 10.4103/jmh.jmh_115_23

Año: 2023

Publicado en: Journal of Mid-Life Health 14, 3 (2023), 196-204
ISSN: 0976-7800

Factor impacto CITESCORE: 1.7 - Health (social science) (Q3) - Medicine (miscellaneous) (Q3)

Factor impacto SCIMAGO: 0.371 - Medicine (miscellaneous) (Q3) - Health (social science) (Q3)

Tipo y forma: Article (Published version)