Laponite for biomedical applications: An ophthalmological perspective

Rodrigo, María J. (Universidad de Zaragoza) ; Cardiel, María J. (Universidad de Zaragoza) ; Fraile, José M. ; Mayoral, José A. (Universidad de Zaragoza) ; Pablo, Luis E. (Universidad de Zaragoza) ; García-Martin, Elena (Universidad de Zaragoza)

Resumen: Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Laponite application in various biomedical areas. This is the first paper to review the potential biomedical applications of Laponite in ophthalmology. The introduction briefly covers the physical, chemical, rheological, and biocompatibility features of different routes of administration. After that, emphasis is placed on 1) drug delivery for antibiotics, anti-inflammatories, growth factors, other proteins, and cancer treatment; 2) bleeding prevention or treatment; and 3) tissue engineering through regenerative medicine using scaffolds in intraocular and extraocular tissue. Although most scientific research is not performed on the eye, both the findings and the new treatments resulting from that research are potentially applicable in ophthalmology since many of the drugs used are the same, the tissue evaluated in vitro or in vivo is also present in the eye, and the pathologies treated also occur in the eye. Finally, future prospects for this emerging field are discussed.

Idioma: Inglés

DOI: 10.1016/j.mtbio.2023.100935

Año: 2023

Publicado en: Materials Today Bio 24 (2023), 100935 [14 pp.]
ISSN: 2590-0064

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/JR22-00057
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/M17-00213
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-1
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-2
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C21
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C22

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Anatomía Patológica (Dpto. Cirugía)