Supplementation for Performance and Health in Patients with Phenylketonuria: An Exercise-Based Approach to Improving Dietary Adherence

González-Lamuño, Domingo ; Morencos, Carmenmelina ; Arrieta, Francisco J. ; Venegas, Eva ; Vicente-Rodríguez, Germán (Universidad de Zaragoza) ; Casajús, José Antonio (Universidad de Zaragoza) ; Couce, Maria Luz ; Aldámiz-Echevarría, Luís

Resumen: Supplementation is crucial for improving performance and health in phenylketonuria (PKU) patients, who face dietary challenges. Proteins are vital for athletes, supporting muscle growth, minimizing catabolism, and aiding muscle repair and glycogen replenishment post-exercise. However, PKU individuals must limit phenylalanine (Phe) intake, requiring supplementation with Phe-free amino acids or glycomacropeptides. Tailored to meet nutritional needs, these substitutes lack Phe but fulfill protein requirements. Due to limited supplement availability, athletes with PKU may need higher protein intake. Various factors affect tolerated Phe levels, including supplement quantity and age. Adhering to supplement regimens optimizes performance and addresses PKU challenges. Strategically-timed protein substitutes can safely enhance muscle synthesis and sports performance. Individualized intake is essential for optimal outcomes, recognizing proteins’ multifaceted role. Here, we explore protein substitute supplementation in PKU patients within the context of physical activity, considering limited evidence.

Idioma: Inglés

DOI: 10.3390/nu16050639

Año: 2024

Publicado en: Nutrients 16, 5 (2024), 639 [15 pp.]
ISSN: 2072-6643

Factor impacto JCR: 5.0 (2024)

Categ. JCR: NUTRITION & DIETETICS rank: 17 / 112 = 0.152 (2024) - Q1 - T1

Factor impacto SCIMAGO: 1.473 - Nutrition and Dietetics (Q1) - Food Science (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)