Exploring the muscle architecture effect on the mechanical behaviour of mouse rotator cuff muscles

Heras-Sádaba, A. (Universidad de Zaragoza) ; Pérez-Ruiz, A. ; Martins, P. (Universidad de Zaragoza) ; Ederra, C. ; Ortiz de Solórzano, C. ; Abizanda, G. ; Pons-Villanueva, J. ; Calvo, B. (Universidad de Zaragoza) ; Grasa, J. (Universidad de Zaragoza)

Resumen: Incorporating detailed muscle architecture aspects into computational models can enable researchers to gain deeper insights into the complexity of muscle function, movement, and performance. In this study, we employed histological, multiphoton image processing, and finite element method techniques to characterise the mechanical dependency on the architectural behaviour of supraspinatus and infraspinatus mouse muscles. While mechanical tests revealed a stiffer passive behaviour in the supraspinatus muscle, the collagen content was found to be two times higher in the infraspinatus. This effect was unveiled by analysing the alignment of fibres during muscle stretch with the 3D models and the parameters obtained in the fitting. Therefore, a strong dependence of muscle behaviour, both active and passive, was found on fibre orientation rather than collagen content.

Idioma: Inglés

DOI: 10.1016/j.compbiomed.2024.108401

Año: 2024

Publicado en: Computers in biology and medicine 174 (2024), 108401 [12 pp.]
ISSN: 0010-4825

Factor impacto JCR: 6.3 (2024)

Categ. JCR: BIOLOGY rank: 7 / 107 = 0.065 (2024) - Q1 - T1
Categ. JCR: MATHEMATICAL & COMPUTATIONAL BIOLOGY rank: 4 / 67 = 0.06 (2024) - Q1 - T1
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 22 / 124 = 0.177 (2024) - Q1 - T1
Categ. JCR: COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS rank: 26 / 175 = 0.149 (2024) - Q1 - T1

Factor impacto SCIMAGO: 1.447 - Health Informatics (Q1) - Computer Science Applications (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/T24-20R
Financiación: info:eu-repo/grantAgreement/ES/MICIU/PID2020-113822RB-C21
Financiación: info:eu-repo/grantAgreement/ES/MICIU/PID2020-113822RB-C22
Financiación: info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U13 Unit-CIBER-BBN

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)