Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis

Van Asbroeck, Stephanie ; Köhler, Sebastian ; van Boxtel, Martin P. J. ; Lipnicki, Darren M. ; Crawford, John D. ; Castro-Costa, Erico ; Lima-Costa, Maria Fernanda ; Blay, Sergio Luis ; Shifu, Xiao ; Wang, Tao ; Yue, Ling ; Lipton, Richard B. ; Katz, Mindy J. ; Derby, Carol A. ; Guerchet, Maëlenn ; Preux, Pierre-Marie ; Mbelesso, Pascal ; Norton, Joanna ; Ritchie, Karen ; Skoog, Ingmar ; Najar, Jenna ; Sterner, Therese Rydberg ; Scarmeas, Nikolaos ; Yannakoulia, Mary ; Dardiotis, Themis ; Rolandi, Elena ; Davin, Annalisa ; Rossi, Michele ; Gureje, Oye ; Ojagbemi, Akin ; Bello, Toyin ; Kim, Ki Woong ; Han, Ji Won ; Oh, Dae Jong ; Trompet, Stella ; Gussekloo, Jacobijn ; Riedel-Heller, Steffi G. ; Röhr, Susanne ; Pabst, Alexander ; Shahar, Suzana ; Rivan, Nurul Fatin Malek ; Singh, Devinder Kaur Ajit ; Jacobsen, Erin ; Ganguli, Mary ; Hughes, Tiffany ; Haan, Mary ; Aiello, Allison E. ; Ding, Ding ; Zhao, Qianhua ; Xiao, Zhenxu ; Narazaki, Kenji ; Chen, Tao ; Chen, Sanmei ; Ng, Tze Pin ; Gwee, Xinyi ; Gao, Qi ; Brodaty, Henry ; Trollor, Julian ; Kochan, Nicole ; Lobo, Antonio (Universidad de Zaragoza) ; Santabárbara, Javier (Universidad de Zaragoza) ; Gracia-Garcia, Patricia (Universidad de Zaragoza) ; Sachdev, Perminder S. ; Deckers, Kay

Resumen: INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.

Idioma: Italiano

DOI: 10.1002/alz.13846

Año: 2024

Publicado en: Alzheimers & Dementia 20, 6 (2024), 3972-3986
ISSN: 1552-5260

Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-23R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103

Tipo y forma: Article (Published version)

Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)