Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography
Sola Fraca, Diego (Universidad de Zaragoza) ; Sánchez Garrigós, Ernesto ; Francisco Moure, Jorge de ; Marín González, Belén (Universidad de Zaragoza) ; Badiola Díez, Juan José (Universidad de Zaragoza) ; Acín Tresaco, Cristina (Universidad de Zaragoza)
Resumen: Neurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopathies (TSEs). Sleep and circadian rhythm disturbances are one of the most common symptoms in patients with neurodegenerative diseases. Currently, one of the main objectives in the study of TSEs is to try to establish an early diagnosis, as clinical signs do not appear until the damage to the central nervous system is very advanced, which prevents any therapeutic approach. In this paper, we provide the first description of sleep disturbance caused by classical scrapie in clinical and preclinical sheep using polysomnography compared to healthy controls. Fifteen sheep classified into three groups, clinical, preclinical and negative control, were analysed. The results show a decrease in total sleep time as the disease progresses, with significant changes between control, clinical and pre-clinical animals. The results also show an increase in sleep fragmentation in clinical animals compared to preclinical and control animals. In addition, sheep with clinical scrapie show a total loss of Rapid Eye Movement sleep (REM) and alterations in Non Rapid Eyes Movement sleep (NREM) compared to control sheep, demonstrating more shallow sleep. Although further research is needed, these results suggest that prion diseases also produce sleep disturbances in animals and that polysomnography could be a diagnostic tool of interest in clinical and preclinical cases of prion diseases.
Idioma: Inglés
DOI: 10.1080/01652176.2024.2349674
Año: 2024
Publicado en: VETERINARY QUARTERLY 44, 1 (2024), 1-9
ISSN: 0165-2176
Financiación: info:eu-repo/grantAgreement/ES/DGA/A19-20R
Tipo y forma: Article (Published version)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-05-22-10:17:33)
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Idioma: Inglés
DOI: 10.1080/01652176.2024.2349674
Año: 2024
Publicado en: VETERINARY QUARTERLY 44, 1 (2024), 1-9
ISSN: 0165-2176
Financiación: info:eu-repo/grantAgreement/ES/DGA/A19-20R
Tipo y forma: Article (Published version)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-05-22-10:17:33)
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Articles > Artículos por área > Sanidad Animal
Record created 2024-05-22, last modified 2024-05-22