Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
Zapata-García, María ; Moratiel-Pellitero, Alba ; Isla, Dolores ; Gálvez, Eva (Universidad de Zaragoza) ; Gascón-Ruiz, Marta ; Sesma, Andrea ; Barbero, Raquel ; Galeano, Javier ; del Campo, Rosa ; Ocáriz, Maitane ; Quílez, Elisa ; Cruellas, Mara ; Ramírez-Labrada, Ariel ; Pardo, Julián (Universidad de Zaragoza) ; Martínez-Lostao, Luis ; Domingo, María Pilar ; Esteban, Patricia ; Torres-Ramón, Irene ; Yubero, Alfonso ; Paño, José Ramón (Universidad de Zaragoza) ; Lastra, Rodrigo
Resumen: Lung cancer is a leading cause of morbidity and mortality globally, with its high mortality rate attributed mainly to non-small cell lung cancer (NSCLC). Although immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized its treatment, patient response is highly variable and lacking predictive markers. We conducted a prospective study on 55 patients with NSCLC undergoing ICI therapy to identify predictive markers of both response and immune-related adverse events (IrAEs) in the airway microbiota. We also analyzed the clinical evolution and overall survival (OS) with respect to treatments that affect the integrity of the microbiota, such as antibiotics and corticosteroids. Our results demonstrated that respiratory microbiota differ significantly in ICI responders: they have higher alpha diversity values and lower abundance of the Firmicutes phylum and the Streptococcus genus. Employing a logistic regression model, the abundance of Gemella was the major predictor of non-ICI response, whereas Lachnoanaerobaculum was the best predictor of a positive response to ICI. The most relevant results were that antibiotic consumption is linked to a lower ICI response, and the use of corticosteroids correlated with poorer overall survival. Whereas previous studies have focused on gut microbiota, our findings highlight the importance of the respiratory microbiota in predicting the treatment response. Future research should explore microbiota modulation strategies to enhance immunotherapy outcomes. Understanding the impact of antibiotics, corticosteroids, and microbiota on NSCLC immunotherapy will help personalize treatment and improve patient outcomes
Idioma: Inglés
DOI: 10.1016/j.heliyon.2024.e33684
Año: 2024
Publicado en: Heliyon 10, 13 (2024), e33684 [13 pp.]
ISSN: 2405-8440
Tipo y forma: Article (Published version)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-07-31-09:22:32)
Visitas y descargas
Idioma: Inglés
DOI: 10.1016/j.heliyon.2024.e33684
Año: 2024
Publicado en: Heliyon 10, 13 (2024), e33684 [13 pp.]
ISSN: 2405-8440
Tipo y forma: Article (Published version)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-07-31-09:22:32)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Inmunología
Articles > Artículos por área > Enfermería
Articles > Artículos por área > Medicina
Record created 2024-07-31, last modified 2024-07-31